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The trial, called CLEAR Outcomes, is a large-scale, long-term study, tracking more than 14, patients with top-line data expected in the second half of The study covers 1, locations in 32 countries around the world.

Esperion shares peaked last February, after the FDA approvals, but since then, the stock has declined.

The offering gives the company a boost in available capital for further work on its development pipeline and its marketing efforts for bempedoic acid.

Chad Messer, covering ESPR for Needham, sees the note offering as a net positive for Esperion. We believe this financing should help put to rest concerns regarding Esperion's balance sheet.

Despite a challenging launch for NEXLETOL and NEXLIZET, product growth has continued in 3Q against the backdrop of a contracting LDL-C market.

This growth trajectory suggests potential for a rapid acceleration when conditions improve," Messer wrote.

See ESPR stock analysis on TipRanks Intercept Pharma ICPT Liver disease is a serious health threat, and Intercept Pharma is focused on developing treatments for some of the more dangerous chronic liver conditions, including nonalcoholic steatohepatitis NASH and primary biliary cholangitis PBC.

Intercept has a research pipeline based on FXR, a regulator of bile acid pathways in the hepatic system. The lead compound, obeticholic acid OCA , is an analog of the bile acid CDCA, and as such can take a role in the FXR pathways and receptors implicated in chronic liver disease.

Treating liver disease through the FXR biology has direct applications for PBC, and is showing promise treating complications from NASH.

The effect on the stock is still felt, and ICPT remains at its week low point. In reaction, in December of , Intercept announced major changes in top-level management, as CEO and President Mark Pruzanski announced he's stepping down effective January 1 of this year.

Pruzanski's dedication to transform the liver space is still strong, and that he will continue to guide ICPT's progress as an advisor and Board member.

Additionally, we have had the pleasure of working closely with Jerry Durso and believe that he will transform the company and lead ICPT's success in growing the PBC market and the path to potential approval and commercial launch of OCA in NASH.

ICPT's Moderate Buy consensus rating is based on 17 reviews, including 8 Buys and 9 Holds. See ICPT stock analysis on TipRanks Gilead Sciences GILD Gilead has had a year like a firework — fast up and fast down.

By November, however, even though remdesivir had been approved, the World Health Organization WHO was recommending against its use, and the COVID vaccines now on the market have made remdesivir irrelevant to the pandemic.

The company has been working, in conjunction with Galapagos GLPG , on development of filgotinib as a treatment for rheumatoid arthritis.

While the drug received EU and Japanese approval in September , the FDA has withheld approval and Gilead announced in December that it was suspending US development efforts on the drug.

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